Variations in KIR Genes: A Study in HIV-1 Serodiscordant Couples

Table 6

Association of KIR2DS1 and KIR2DS4-del variant with HIV-1 viral load in HSPs.

KIR gene	HSPs 𝑁 (%)
	Viral load			Linear regression values
	Low (<5000 copies/mL)	Medium (5000–10,000 copies/mL)	High (>10,000 copies/mL)	𝛽	𝑃
KIR2DS1+	15 (50.0%)	8 (26.7%)	7 (23.3%)	0.688	0.000*
KIR2DS1−	1 (6.9%)	2 (11.7%)	14 (82.3%)	0.644	0.007*
KIR2DS4-del+	14 (36.8%)	3 (7.9%)	21 (55.3%)	0.871	0.000*
KIR2DS4-del−	3 (33.3%)	—	6 (66.7%)	0.571	0.181

HSPs: HIV-1 seropositive spouses; KIR: killer immunoglobulin receptor; %: percentage; del: deleted; +: gene present; −: gene absent; ^∗𝑃 values <0.05 are considered statistically significant; 𝛽: beta value.