Systematic Expression Profiling Analysis Identifies Specific MicroRNA-Gene Interactions that May Differentiate between Active and Latent Tuberculosis Infection

Table 2

Selected blood- and lung-targeting microRNAs and their validated or predicted target genes.

microRNA	Target genes
TB versus control downregulated
hsa-let-7i-5p	ADM, HMGA2, LRRK2, SERPING1, TLR4
LTBI versus control upregulated
hsa-miR-107	BTG2,  EIF5
hsa-miR-142-3p^a,b	KLF4,  POMC,  JUN,  PMAIP1,  PDGFRB,  SIK1
hsa-miR-16-5p	SIK1,  NR4A1,  IER2,  AGPAT4,  CSRNP1,  PLEKHG2,  CD69
hsa-miR-21-5p^b	CD69,  H3F3B,  TAF1C,  TRIB1,  PMAIP1
hsa-miR-22-3p	H3F3B,  TAF1C,  TRIB1,  PMAIP1,  BTG2
hsa-miR-221-3p	FOS,  ZBTB24,  EIF1,  MYLIP,  NAP1L5,  SOCS3
hsa-miR-223-3p^b	RHOB,  CXCL2
LTBI versus TB upregulated
hsa-miR-146a-5p^b	ST20
hsa-miR-150-5p^b	CPD,  ARRB2,  FFAR2,  NUP214,  PNMA3,  C20orf24,  C16orf57
hsa-miR-16-5p	CPD,  C15orf39,  C16orf57,  TUBA1A
hsa-miR-221-3p	ANXA1,  FOS,  PLAUR,  TIMP2,  C16orf57,  MIDN

validated microRNA-target interaction; ^bindicates that these microRNAs have been implicated in tuberculosis.