Synthesis and Gene Silencing Properties of siRNAs Containing Terminal Amide Linkages
Figure 7
Stability of natural and modified siRNAs in 100% fetal bovine serum at 37°C. After incubation, siRNAs were analyzed by PAGE and ethidium bromide staining. Gel images were captured by ChemiDoc XRS (Bio-Rad) and RNA bands were quantified by Image Lab software (Bio-Rad). Signal intensity values at t 0 were set at 1.
