Synthesis and Gene Silencing Properties of siRNAs Containing Terminal Amide Linkages

Figure 8

Stereoview of the predicted binding mode of the 3′-OH-PNA AS of siRNA 17 in the hAgo 2 X-ray structure. For clarity reasons, the PNA structure is depicted (yellow sticks) while the RNA backbone is shown as an orange transparent ribbon. The protein is depicted as green sticks (interacting residues) and ribbons and white transparent surface. H-bonds are indicated as yellow dashed lined.