Research Article

Synthesis and Preclinical Characterization of [18F]FPBZA: A Novel PET Probe for Melanoma

Figure 5

(a) Representative coronal (top) and transaxial (bottom) [18F]FPBZA microPET images of mice bearing B16F0 tumor, A375 tumor, and turpentine-induced inflammation. Static microPET images were obtained at 0.5, 1, and 2 h after bolus injection of 1.85–3.7 MBq of [18F]FPBZA via the tail vein. Arrows indicated tumors and arrow head indicated inflammation regions. (b) Time-activity curves of tumors, inflammation lesion, and normal tissues in various mouse models derived from microPET images after intravenous injection of [18F]FPBZA. SUVs were expressed in  %ID/g ± SD ().
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