Hypothalamus-Anchored Resting Brain Network Changes before and after Sertraline Treatment in Major Depression

Table 2

Significant changes in hypothalamus-related connectivity network derived from after versus before medication (𝑃<0.001, FDR corrected).

(a) Increased

		Talairach			𝑡 value	Voxels
		𝑥	𝑦	𝑧
Frontal
DLPFC BA/44	R	48	16	10	3.08	44
OFC BA/10	R	8	38	−7	2.25	44
SFG BA/8	R	14	39	48	2.33	22
Precentral gyrus BA/44	R	44	12	9	3.20	20
Limbic
ACC BA/24	R	6	31	0	2.76	45
Hippocampus	R	33	−14	−18	3.23	16
Subcortical
Insula BA/13	R	42	12	10	2.61	43
Putamen	R	24	8	−2	2.09	28
Caudate	R	8	10	11	3.57	82
Claustrum	R	32	−3	13	2.54	25
Temporal
STG BA/22	R	63	−40	20	2.37	27
Parietal
IPL BA/40	R	55	−44	22	2.40	38
SG BA/40	R	57	−37	30	2.33	24

(b) Decreased

		Talairach			𝑡 value	Voxels
		𝑥	𝑦	𝑧
Frontal
IFG BA 47	L	53	17	−6	−2.87	54
IFG BA 9	R	−53	11	31	−2.35	427
Precentral gyrus	L	−49	−8	43	−2.29	16
MFC BA 6/8	R	6	−1	61	−2.98	144
SFG BA 6	L	−2	28	54	−2.86	112
	R	8	−1	63	−3.04	152
Limbic
Cingulate gyrus	L	−6	6	40	−2.63	155
BA 32	R	4	10	40	−2.32	88
Temporal cortex	L
MTL BA/37	R	−53	−66	7	−2.48	48
Parietal cortex
Precuneus	L	−4	−73	50	−2.68	137
BA 7	R	4	−44	45	−2.19	37
Subcortical
Thalamus	L	−4	−4	4	−2.34	30
	R	8	−9	8	−2.75	28
Cerebellum
Declive	L	−16	−82	−16	−3.46	455
	R	36	−75	−21	−3.07	290
Uvula	L	−28	−71	−23	−3.19	111
	R	34	−63	−25	−3.24	110

Abbreviations: BA: Brodmann area; DLPFC: dorsolateral prefrontal cortex; OFC: orbitofrontal cortex; SFG: superior frontal gyrus; ACC: anterior cingulate cortex; STG: superior temporal gyrus; IPL: inferior parietal lobule; SG: supramarginal gyrus; IFG: inferior frontal gyrus; MFC: medial frontal cortex; MTL: medial temporal lobule.