Effect of Ca²⁺ Efflux Pathway Distribution and Exogenous Ca²⁺ Buffers on Intracellular Ca²⁺ Dynamics in the Rat Ventricular Myocyte: A Simulation Study

Figure 4

Effect of 10 mM EGTA (a) and 10 mM BAPTA (b) on the time course of total 𝐼_NaCa, 𝐼_pCa, 𝐽_up, and 𝐼_Ca and Ca²⁺ transients in the t-tubular dyadic space ([Ca²⁺]_dt) and in the cytosol ([Ca²⁺]_c) during the first 0.5 s of steady-state cycle at 1 Hz (action potentials elicited by 1 ms current clamps). The solid and dashed lines show, respectively, the traces obtained in control conditions and in the presence of the buffers in the intracellular space.

(a)

(b)