Intraportal Infusion of Ghrelin Could Inhibit Glucose-Stimulated GLP-1 Secretion by Enteric Neural Net in Wistar Rat
Figure 3
Plasma concentrations of glucose (a), insulin (b), and GLP-1 (c) during ghrelin infusion with or without phentolamine in the OGTT; phentolamine (15 ng/kg/mL) and ghrelin (1 ng/kg/mL) were infused into the portal vein (i.p.) from 0 to 60 min at a rate of 1 mL/h using a micropump. A 20% glucose solution (1 g/kg) was administered through stomach catheter orally. Data are represented as mean ± SE. Open squares, saline i.p. closed squares, ghrelin i.p.; and closed triangles, ghrelin with phentolamine i.p. versus, ghrelin i.p. group (); versus, ghrelin i.p. group ().
