Intraportal Infusion of Ghrelin Could Inhibit Glucose-Stimulated GLP-1 Secretion by Enteric Neural Net in Wistar Rat
Figure 4
Plasma concentrations of glucose (a), insulin (b), and GLP-1 (c) during KP-102 infusion with or without ghrelin in the OGTT. KP-102 (1 μg/kg/mL) and ghrelin (1 ng/kg/mL) were infused into the portal vein (i.p.) from 0 to 60 min at a rate of 1 mL/h using a micropump. A 20% glucose solution (1 g/kg) was administered through stomach catheter orally. Data are represented as mean ± SE. Open squares, saline i.p. group (); closed triangles, KP-102 i.p. group (); open triangles, KP-102 with ghrelin i.p. group (). versus saline i.p.; versus saline i.p. with sham operation group.
