Multiple Effects of Berberine Derivatives on Colon Cancer Cells

Figure 3

BBR effect on cell survival. (a) MTT metabolic and (b) cytotoxicity assay performed on HCT116 and SW613-B3 cell lines and normal FO46 fibroblasts treated with 1 and 10 µM BBR and NAXs for 24 h (black columns) followed by a 24 h recovery in fresh medium (white columns). (c) Colony forming ability of HCT116 and SW613-B3 cells treated with 0.5 µM (black columns) and 5 µM (white columns) NAXs for 24 h and further grown for 10 days in drug free medium. ^∗𝑃<0.05; ^∗∗𝑃<0.01; and ^∗∗∗𝑃<0.001.

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