Molecular Mechanism Underlying Lymphatic Metastasis in Pancreatic Cancer

Table 2

Metastasis-related miRNAs in pancreatic cancer.

miRNA	Impact on metastatic processes	Target genes	References
miR-146a/b	Suppressing	EGFR, IRAK-1,; MMP16, and NF-𝜅B	[61]
let-7 family	Suppressing	HMGA2, MYC, NOTCH, RAS,; COL1A2, MT1-MMP, MMP-14	[62]
miR-141, and miR-200a/b/c,; miR-429	Suppressing	ZEB1, ZEB2, E-CADHERIN, N-CADHERIN	[38]
miR-34 family	Suppressing	NOTCH, BCL-2, NANOG, SOX2, and N-MYC	[39]
miR-20a	Suppressing	STAT3	[63]
miR-126	Suppressing	ADAM9	[64]
miR-150	Suppressing	MUC4	[36]
miR-30 family	Suppressing	VIMENTIN and SNAIL-1	[65]
miR-143/145	Suppressing	KRAS, RREB1	[34]
miR-486	Promoting	CD40	[66]
miR-224	Promoting	CD40	[66]
miR-10a, miR-10b	Promoting	HOXA1, HOXB1, and HOXB3	[40, 41]
miRNA-27a	Promoting	SPRY2	[42]