Genetics of Type 2 Diabetes: Insights into the Pathogenesis and Its Clinical Application

Table 2

Type 2 diabetes susceptibility loci identified in East Asians.

	Locus	SNP	Chr.	Position	Allele (risk/other)	RAF*	OR	Probable mechanism
2009	KCNQ1 [26]	rs2237892	11	2796327	C/T	0.683	1.43	β-Cell function	GWAS
2010	UBE2E2 [27]	rs7612463	3	23311454	A/C	0.134	1.19	Unknown	GWAS
2010	C2CD4A-C2CD4B [27]	rs7172432	15	60183681	A/G	0.42	1.13	Unknown	GWAS
2010	SPRY2 [28]	rs1359790	13	79615157	G/A	0.273	1.15	Unknown	GWAS
2010	CDC123/CAM K1D [28]	rs10906115	10	12355003	A/G	0.561	1.13	Unknown	GWAS
2010	SRR [29]	rs391300	17	2163008	G/A	0.367	1.28	β-Cell function	GWAS
2010	PTPRD [29]	rs17584499	9	8869118	T/C	0.226	1.57	Insulin action	GWAS
2011	MAEA [30]	rs6815464	4	1299901	C/G	0.640	1.13	Unknown	GWAS
2011	PSMD6 [30]	rs831571	3	64023337	C/T	0.688	1.09	Unknown	GWAS
2011	ZFAND3 [30]	rs9470794	6	38214822	C/T	0.203	1.12	Unknown	GWAS
2011	GCC1-PAX4 [30]	rs6467136	7	126952194	G/A	0.182	1.11	Unknown	GWAS
2011	KCNK16 [30]	rs1535500	6	39392028	T/G	0.398	1.08	β-Cell function	GWAS
2011	PEPD [30]	rs3786897	19	38584848	A/G	0.547	1.1	Unknown	GWAS
2011	FITM2-R3HD [30]	rs6017317	20	42380380	G/T	0.545	1.09	β-Cell function	GWAS
2011	GLIS3 [30]	rs7041847	9	4277466	A/G	0.529	1.1	β-Cell function	GWAS
2012	ANK1 [31]	rs515071	8	41,638,405	C/T	0.8	1.18	Unknown	GWAS
2013	GRK5 [32]	rs10886471	10	121139393	C/T	0.756	1.12	Insulin action	GWAS
2013	RASGRP1 [32]	rs7403531	15	36610197	T/C	0.317	1.1	β-Cell function	GWAS
2013	PAX4 [33]	rs10229583	7	127034139	G/A	0.829	1.18	Unknown	GWAS
2013	MIR129-LEP [34]	rs791595	7	127650038	A/G	0.08	1.17	Unknown	GWAS
2013	SLC16A13 [34]	rs312457	17	6881117	G/A	0.078	1.2	Unknown	GWAS
2013	GPSM1 [34]	rs11787792	9	138371969	A/G	0.874	1.15	Unknown	GWAS

∗Data were derived from HapMap East Asian or original studies. Position is given for NCBI Build 36.
SNP: single nucleotide polymorphism; Chr.: chromosome; RAF: risk allele frequency; OR: odds ratio.