Genetics of Type 2 Diabetes: Insights into the Pathogenesis and Its Clinical Application

Table 3

Type 2 diabetes susceptibility loci identified in South Asians.

	Locus	SNP	Chr.	Position	Allele (risk/other)	RAF*	OR	Probable mechanism
2011	ST6GAL1 [35]	rs16861329	3	188149155	G/A	0.86	1.09	β-Cell function	GWAS
2011	HNF4A [35]	rs4812829	20	42422681	A/G	0.29	1.09	β-Cell function	GWAS
2011	VPS26A [35]	rs1802295	10	70601480	A/G	0.26	1.08	Unknown	GWAS
2011	AP3S2 [35]	rs2028299	15	88175261	C/A	0.31	1.1	Unknown	GWAS
2011	HMG20A [35]	rs7178572	15	75534245	G/A	0.52	1.09	Unknown	GWAS
2011	GRB14 [35]	rs3923113	2	165210095	A/C	0.74	1.09	Insulin action	GWAS
2013	TMEM163 [36]	rs998451	2	135145758	G/A	1	1.56	β-Cell function	GWAS
2013	SGCG [37]	rs9552911	13	22762657	A/G	0.07	0.67	Unknown	GWAS

∗Data were derived from HapMap East Asian or original studies. Position is given for NCBI Build 36.
SNP: single nucleotide polymorphism; Chr.: chromosome; RAF: risk allele frequency; OR: odds ratio.