Determination of Critical Parameters of Drug Substance Influencing Dissolution: A Case Study

Figure 4

Dependence of dissolved amounts [%] of individual API samples AS-1–AS-5 ((a), (c)) and individual tablets TS-1–TS-5 ((b), (d)) in the 10th minute on particle size (x ₁₀ and x ₉₉ [μm]). Samples with boundary values AS-1, AS-2, TS-1, and TS-2 are marked by empty symbols. The data represent the mean ± SD of five samples.

(a)

(b)

(c)

(d)