Review Article
Is Contrast Medium Osmolality a Causal Factor for Contrast-Induced Nephropathy?
Table 2
Clinical studies for CIN comparison of LOCM* versus IOCM** (mainly I.V.).
| Authors (date) | Patients evaluated (originally included) | CIN absolut1 (relative2) LOCM | CIN absolut1 (relative2) IOCM | Agent superiority |
| Barrett et al. (2006), [14] | 153 (166) | 0/77 (3/77) | 2/76 (3/76) | LOCM = IOCM |
| Kuhn et al. (2008), [15] | 248 (264) | (6/123) | (7/125) | LOCM = IOCM |
| Thomsen et al. (2008), [16] | 148 (184) | 0/76 (4/76) | 5/72 (5/72) | LOCM > IOCM |
| Nguyen et al. (2008), [17] | 126 (117) | 10/56 (15/56) | 3/61 (5/61) | IOCM > LOCM |
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LOCM: low osmolality contrast media.
**IOCM: iso-osmolar contrast media. SCr: serum creatinine. CIN: contrast-medium induced nephropathy.
1SCr increase ≥0.5 mg/dL.
2SCr increase ≥25%.
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