Prolonged Hypocalcemic Effect by Pulmonary Delivery of Calcitonin Loaded Poly(Methyl Vinyl Ether Maleic Acid) Bioadhesive Nanoparticles

Table 6

Duration of hypocalcemic effect and maximum reduction in blood calcium levels after pulmonary and iv administration of sCT solution and sCT nanoparticles dispersion. Results are expressed as mean ± SE of seven rats.

Studied parameter	Intravenous injection; of sCT solution	Pulmonary administration
		sCT solution	sCT nanoparticles dispersion
Dose (µg kg^−1)	5	25	25
Blood calcium level compared to normal level (%)	72±7.5	82.5±9.5	59±5
Duration of hypocalcemia (h)	0.5–1	3-4	12–24
AAC0--48(% h)	211.0±63.0	302.1±100.9	1259.9±147.2