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| Author/year of publication | Baseline characteristics | Pain relief | Disability | QoL | Kyphotic angle/VH | Cement leakage | New fractures | Conclusion |
|
(1) Wardlaw et al. 2009 [22], Boonen et al. 2011 [27]
(FREE)
RCT | (1) BKP (149) versus NSM (151)
(2) Acute number
(3) 1 mo, 3 mo, 6 mo, 12 mo | VAS score
BKP superior to NSM() | RM
BKP superior to NSM | SF-36
BKP superior to NSM
EQ-5D
BKP superior to NSM | NR | 27%, none symptomatic | BKP: 33%
NSM: 25% : NR | BKP is superior to NSM in acute VCFs in terms of pain and QOL/disability. Differences between groups diminished by 1 year. |
|
(2) Liu et al. 2010 [44]
RCT | (1) BKP (50) versus VP (50)
(2) Acute number
(3) Postop, 6 mo | VAS score
BKP equivalent to VP | NR | NR | BKP superior to VP () | NR | BKP: 2
VP: 0 | Similar clinical results between BKP and VP. Better height restoration with BKP. |
|
(3) Rousing et al. 2009 [11], 2010 [12]
RCT | (1) VP (26) versus NSM (24)
(2) Acute number
(3) 3 mo, 12 mo | VAS score
VP equivalent to NSM up to 1 y () | NR | SF36
VP equivalent to NSM up to 1 y | NR | NR | VP/NSM:
RR: 1.3 | No difference between VP and NSM in 3 months and 12 months |
|
(4) Voormolen et al. 2007 (VERTOS I) [21]
RCT | (1) VP (18) versus NSM (16)
(2) Acute number
(3) Postop, 2 w | VAS score
VP superior to NSM 14/16 pts crossovered from NSM to VP
| RM
VP superior to NSM | QUALEFFO
Mixed results in the subscores between groups | NR | NR | NR | VP is more effective than NSM in pain relief and function in the immediate postop period (2 weeks) |
|
(5) Buchbinder et al. 2009 [4]
RCT—SHAM group | (1) VP (38) versus SHAM (40)
(2) Acute number (also subacute)
(3) 1 w, 1 mo, 3 mo, 6 mo | VAS score
VP equivalent to SHAM | RM
VP equivalent to SHAM | AQoL, QUALEFFO, EQ-5D
VP equivalent to SHAM | NR | 37%, none symptomatic | VP: 3
SHAM: 4 | No difference between VP and SHAM up to 6 months |
|
(6) Kallmes et al. 2009 (INVEST) [5]
RCT—SHAM group | (1) VP (68) versus SHAM (63)
(2) Subacute number(also Acute and Chronic)
(3) Postop, 2 w, 1 mo, 3 mo | VAS score
VP equivalent to SHAM Higher crossover rate in SHAM () | RM
VP equivalent to SHAM () | EQ-5D, SF-36
VP equivalent to SHAM | NR | NR | NR | No difference between VP and SHAM up to 1 month |
|
(7) Klazen et al. 2010 (VERTOS II) [19]
RCT | (1) VP (101) versus NSM (101)
(2) Acute number
(3) Postop, 1 w, 1 mo, 3 mo, 6 mo, 1 y | VAS score
VP superior to NSM
() | RM
VP superior to NSM
() | QUALEFFO, EQ-5D
VP superior to NSM
() | NR | 72% had asymptomatic cement leakage | VP equivalent to NSM () | VP is more effective than NSM in acute fractures for at least 1 year. |
|
| (8) Endres and Badura 2012 [38]RCT | BKP versus UNI BKP versus VP | All equivalent | All equivalent | | | VP more cement leak | | VP procedure of choice due to less time and RT (but cement leak) |
|
(9) Vogl et al. 2013 [45]
RCT | KP-CD (49) versus VP (28) | | | | equivalent | VP more cement leak | 3 in VP, 2 in KP | KP-CD reduces posterior cement leak |
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