Structural Basis of Binding and Rationale for the Potent Urease Inhibitory Activity of Biscoumarins

Figure 5

Showing the interaction of compound 7 (blue) and 3 (red) with urease (Bacillus pasteurii). Ligand 7 is penetrated inside the active site and interacted with nickel metallocentre of urease but ligand 3 is unable to reach the narrow pocket.