Genetic Polymorphisms in Glutathione (GSH-) Related Genes Affect the Plasmatic Hg/Whole Blood Hg Partitioning and the Distribution between Inorganic and Methylmercury Levels in Plasma Collected from a Fish-Eating Population

Table 5

Multivariate regression parameters for the associations between genotype and total Hg in blood (THgB) and total Hg, methylmercury, and inorganic Hg in plasma (THgP, MeHgP, and IHgP, resp.) as well as the ratio THgP/THgB.

Genotypes	THgB^d		THgP^d		MeHgP^d		IHgP^d		THgP/THgB^d
	𝛽^𝑒	𝑃	𝛽	𝑃	𝛽	𝑃	𝛽	𝑃	𝛽	𝑃
GSTM1
Present	—	—	—	—	—	—	—	—	—	—
Null	0.21	0.13	0.22	0.035	0.30	0.050	0.18	0.10	0.16	0.88
GSTT1
Present	—	—	—	—	—	—	—	—	—	—
Null	0.14	0.31	0.10	0.34	0.18	0.24	0.090	0.45	−0.040	0.71
GSTP1 ^a
Ile/Ile	—	—	—	—	—	—	—	—	—	—
Ile/Val + Val/Val	−0.10	0.49	−0.12	0.27	−0.79	0.59	−0.11	0.36	−0.018	0.87
GCLM ^b
CC	—	—	—	—	—	—	—	—	—	—
CT + TT	0.12	0.38	−0.08	0.41	−0.16	0.29	−0.020	0.88	−0.21	0.050
GCLC ^c
CC	—	—	—	—	—	—	—	—	—	—
CT + TT	0.34	0.25	0.45	0.046	0.69	0.038	0.36	0.14	0.12	0.61

ars1695; brs41307970; crs17883901; dNatural ln-transformed.
eUnstandardized beta (β) coefficients for the 𝛽₁ × genotype term (categorical) adjusted for covariates. The genotype denoted first is used as reference. Multivariate model: Hg biomarkers = α + 𝛽₁ × genotype + 𝛽₂ × fish intake + 𝛽₃ × age + 𝛽₄ × gender.