Chromatographic Fingerprint Analysis and Effects of the Medicinal Plant Species Mitracarpus frigidus on Adult Schistosoma mansoni Worms

Table 2

Results obtained in mice experimentally infected with 50±10 cercariae of Schistosoma mansoni (LE strain) treated with Mitracarpus frigidus, orally, after 60 days of infection.

Groups	Worm distribution
	Liver		Mesentery		Total
	Means of worms; (M/F)	Reduction^c; (%)	Means of worms; (M/F)	Reduction^c; (%)	Global means; (M/F)	Global reduction^c; (%)
Negative control	4.6±1.0	—	19.2±1.4	—	23.0±1.0	—
Praziquantel; 200 mg/kg	2.4±0.7^a	48	9.4±1.7^a	51	11.8±2.0^a	49
MFM; 100 mg/kg	0.4±0.4^a,b	91	6.8±1.6^a	65	7.2±1.9^a	69
MFM; 300 mg/kg	1.6±0.8^a	65	8.0±1.5^a	58	9.6±1.7^a	58

The values shown are mean ± SEM (𝑛=8). ^aStatistically different from the negative control group. ^bStatistically different from the positive control group (praziquantel) (ANOVA followed by the Bonferroni test, 𝑃<0.05). ^cPercentage reduction (%) = {1 − (mean of worms in the negative control group/mean of worms in the groups treated)}  × 100.