Chromatographic Fingerprint Analysis and Effects of the Medicinal Plant Species Mitracarpus frigidus on Adult Schistosoma mansoni Worms

Table 3

Effects of Mitracarpus frigidus methanolic extract (MFM) treatment on the biochemical and hematological parameters, after 60 days of infection.

	Noninfected groups				Infected groups
	Group A	Group B	Group C	Group D	Group E	Group F	Group G	Group H
	Negative control	Praziquantel	MFM	MFM	Negative control	Praziquantel	MFM	MFM
		200 mg/kg	100 mg/kg	300 mg/kg		200 mg/kg	100 mg/kg	300 mg/kg
Total protein (g/dL)	13.2±0.2	10.6±0.3	12.5±0.5	11.4±0.5	5.1±0.2	4.8±0.2	5.7±0.2	5.4±0.2
Albumin (g/dL)	4.4±0.4	3.0±0.2^a	2.3±0.1^a,b	1.8±0.1^a,b	2.8±0.2	2.7±0.2	2.7±0.2	3.1±0.2
Globulin (g/dL)	7.9±1.4	7.6±0.5	10.2±0.6^a,b	9.8±0.4^a,b	2.3±0.2	2.0±0.3	3.0±0.3^c,d	2.4±0.3
A/G	0.5±0.1	0.4±0.05	0.2±0.02	0.2±0.02	1.3±0.3	2.1±0.6^c	1.0±0.1^d	1.6±0.3
ALP (U/L)	17.5±1.5	22.7±2.1	12.2±1.4^b	7.7±1.9^a,b	55.1±5.0	38.7±3.2^c	38.7±3.9^c	41.7±3.4^c
AST (U/L)	10.9±1.3	18.6±4.3^a	8.5±1.4^b	13.2±3.1	44.6±3.8	21.0±3.5^c	26.8±1.9^c	32.3±3.0^c,d
ALT (U/L)	17.9±2.8	9.3±1.6^a	11.6±2.7	6.3±1.0^a	33.3±2.3	29.8±3.1	4.2±0.4^c,d	14.6±3.5^c,d
Total leukocytes (10^3/𝜇L)	5.1±0.4	4.3±0.4	4.8±0.4	5.0±0.4	8.4±0.6	5.6±0.7^c	5.7±0.4^c	5.2±0.4^c
Basophil (%)	1.0±0	1.0±0	1.0±0	1.0±0	1.0±0	1.1±0.1	1.2±0.1	1.2±0.1
Eosinophil (%)	2.1±0.4	2.3±0.2	1.9±0.1	2.1±0.1	20.4±1.2	11.2±1.3^c	5.1±1.0^c,d	6.5±1.0^c,d
Monocyte (%)	9.4±0.5	7.4±0.7	5.4±0.7^a	5.2±1.2^a	19.6±2.2	10.3±1.3^c	4.6±1.0^c,d	9.1±1.4^c
Neutrophil (%)	43.3±3.5	53.6±2.5^a	49.0±1.4	49.7±2.3	39.8±2.6	59.4±2.3^c	65.8±2.0^c	65.4±1.4^c
Lymphocyte (%)	42.4±2.6	34.8±2.5^a	45.8±2.7^b	47.2±2.0^b	17.4±2.5	13.9±1.2	20.5±1.5^d	16.9±1.3

The values shown are mean ± SEM (𝑛=10). ^aStatistically different from the noninfected, negative control Group A. ^bStatistically different from the noninfected, positive control Group B. ^cStatistically different from the infected, negative control Group E. ^dStatistically different from the infected, positive control Group F (ANOVA followed by the Bonferroni test, 𝑃<0.05).