New SPECT and PET Radiopharmaceuticals for Imaging Cardiovascular Disease

Table 10

PET Radiotracers for Imaging Autonomic Dysfunction in Heart Failure.

^11C-Meta-Hydroxyephedrine (^11C-m-HED); (i) ^11C-meta-hydroxyephedrine (^11C-m-HED) similar to ^123I-MIGB; (ii) targets sympathetic nerve terminals with a similar metabolic profile to norepinephrine; (iii) not metabolized by postsynaptic COMT and monoamine oxidase (MOA) metabolism; (iv) retention reflects the capacity for rapid reuptake via NET; (v) ^11C {𝑡1/2 = 20.3 min, 𝐸𝛾 = 511 keV, Maximum 𝐸𝛽^+ = 0.96 MeV, Average 𝛽^+ range; in H2O (FWHM) = 1.1 mm}; (vi) ^11C[Cyclotron production {^14N(p,𝛼)^11C or ^10B(d,n)^11C}]