New SPECT and PET Radiopharmaceuticals for Imaging Cardiovascular Disease

Table 2

Examples of Novel Technetium-99m SPECT Radiotracers for Myocardial Perfusion Imaging.

	[^99mTcN(PNP5)(DBODC)]^+; (i) heart/liver ratio at 30 min PI was 6.01±1.45 (2-times higher than ^99mTc-sestamibi); (ii) heart/liver ratio at 120 min PI was 21.20±1.45 (~8-times higher than ^99mTc-sestamibi)
	[^99mTcN(PNP5)(MPO)]^+ = {^99mTcN-MPO}; (i) high heart uptake (2.45±0.58 %ID/g at 5 min PI); (ii) long myocardial retention (2.44±0.46 %ID/g at 120 min PI); (iii) 4-times faster liver clearance than ^99mTc-sestamibi and excellent heart/liver ratios (12.75±3.34 g at 30 min PI)
	[^99mTc(PNP)(CO)3]; (i) overall similar to ^99mTc-tetrofosmin and ^99mTc-sestamibi with higher first pass extraction (2.5-times that of ^99mTc-sestamibi),; (ii) longer retention in cardiac myocytes, rapid hepatic and pulmonary clearance
	[^99mTc(CO)3-TMEOP]^+; (i) high heart uptake (6.98±1.66 %ID/g at 40 min PI); (ii) faster liver clearance than ^99mTc-sestamibi and ^99mTc-tetrofosmin; (iii) stable complex after 24-hours in 0.1 M PBS (pH = 7.4, 37°C)