New SPECT and PET Radiopharmaceuticals for Imaging Cardiovascular Disease

Table 3

Non-commercial/Novel SPECT Radiotracers for Myocardial Perfusion Imaging.

^123I-Rotenone (^123I-CMICE-013); (i) rotenone derivative designed as a mitochondrial complex 1 (MC-1) inhibitor; (ii) high myocardial uptake, high first pass extraction, slow washout because of specific MC-1 binding, very good target-to-background ratio; (iii) ^123I [𝑡1/2 = 13.2 h, 𝐸𝛾 = 159 keV (83%), electron capture]; (iv) ^123I[Cyclotron production {^124Xe(p,n)^123I}]