New SPECT and PET Radiopharmaceuticals for Imaging Cardiovascular Disease

Table 5

Non-commercial/Novel PET Radiotracers for Myocardial Perfusion Imaging [53].

(2-tert-Butyl-4-Chloro-5-[4-(2-(^18F)Fluoroethoxymethyl)-; Benzyloxy]-2H-Pyridazin-3-1 (^18F-Flurpiridaz); (i) structural analogue of pyridaben (an NADH:ubiquinone oxidoreductase inhibitor of mitochondrial complex-1); (ii) MC-1 is a protein predominantly in myocardial cells; (iii) rapid myocardial uptake, high first pass extraction, slow washout due to specific MC-1 targetry; (iv) currently in Phase III clinical trials; (v) ^18F [{𝑡1/2 = 109.7 min, 𝐸𝛾 = 511 keV, Maximum 𝐸𝛽^+ = 635 keV, Average 𝛽^+ range in H2O (FWHM) = 1.0 cm}]; (vi) ^18F[Cyclotron production {^18O(p,n)^18F}]