Geometric Analysis of Alloreactive HLA α-Helices

Figure 5

Area of ruled surface between MHC 𝛼-helices. From distances between splines and distances between rulings, the total intrahelical area, 𝐴, is computed along a 250 ns MD trajectory for three different molecular systems (B4402, B4403, and B4405), and three different polynomial degrees (𝑚=2, (a); 𝑚=3, (b); and 𝑚=4, (c)).

(a)

(b)

(c)