Clinical Utility of Ammonia Concentration as a Diagnostic Test in Monitoring of the Treatment with L-Asparaginase in Children with Acute Lymphoblastic Leukemia

Table 2

The parameters assessing the ability of the ammonia concentration to recognize low (<100 IU/L) ASP activity (95% CI in brackets).

	The ammonia concentration after ASP administration
	24 hours ≤ 64 𝜇mol/L	3 days ≤ 29 𝜇mol/L
Sensitivity	0.64 (0.51–0.76)	0.76 (0.62–0.87)
Specificity	0.75 (0.72–0.76)	0.65 (0.59–0.71)
Positive predictive value	0.30 (0.24–0.35)	0.27 (0.22–0.30)
Negative predictive value	0.93 (0.90–0.95)	0.94 (0.91–0.96)