Intrinsic Functional Connectivity Networks in Healthy Elderly Subjects: A Multiparametric Approach with Structural Connectivity Analysis
Figure 2
The effect of spatial and temporal filtering exemplified for one representative subject. Most informative orthogonal slices (left column) in the MNI stereotaxic space show the default mode network (DMN) computed for a seed-voxel in posterior cingulate cortex (PCC, xyz, 0−5526) for (a) motion corrected and resampled data to 1 mm cubic grid, (b) after spatial smoothing with a 3D-Gaussian kernel (8 mm FWHM), and (c) after temporal linear detrending and bandpass filtering (0.01–0.08 Hz). Time rows with corresponding frequency spectrum (right column) for the seed-voxel (red trace) and a voxel-time course extracted from the medial prefrontal cortex (mPFC, green trace, x y z, 1/50/22). Connectivity strengths are shown in hot colors, thresholded for corresponding to and overlaid on the individual MPRAGE (1.0 × 1.0 × 1.0 mm3).
