Heterogeneous Downregulation of Angiotensin II AT1-A and AT1-B Receptors in Arterioles in STZ-Induced Diabetic Rat Kidneys

Table 4

The relative numbers of angiotensin II AT1 receptor subtypes in SMCs in the afferent and efferent arterioles in STZ-induced diabetic and normal rat kidneys. The normal state in the number of AT1-B receptors between the afferent and efferent arteriole is changed to equal in diabetes, because of enhanced downregulation of AT1-B receptor in the efferent arteriole.

		𝑛	Afferent arterioles	Efferent arterioles	Difference	𝑃
			Mean (CV)
Angiotensin II AT1-A receptors in SMCs surface (signals/um^3)	Normal	4	0.215 (0.18)	0.283 (0.19)	24%	NS
Angiotensin II AT1-B receptors in SMCs surface (signals/um^3)	Normal	4	0.176 (0.11)	0.312 (0.38)	44%	0.034
Angiotensin II AT1-A receptors in SMCs surface (signals/um^3)	Diabetic	5	0.062 (0.73)	0.043 (0.9)	30%	NS
Angiotensin II AT1-B receptors in SMCs surface (signals/um^3)	Diabetic	5	0.053 (0.19)	0.064 (0.34)	17%	NS