Antiviral Action of Synthetic Stigmasterol Derivatives on Herpes Simplex Virus Replication in Nervous Cells In Vitro

Figure 1

Effect of stigmasterol derivatives 1 and 2 on HSV-1 multiplication. PC-12 (square), Neuro-2a (triangle), and SH-SY5Y cells (circle) were infected with HSV-1 KOS (m.o.i.: 1) and incubated for 1 h at 37°C. After adsorption, cells were covered with DMEM/F12 2%. At 24, 48, and 72 h after infection supernatants were harvested and viral titres were determined by plaque assay. Data are mean values from two separate experiments ± SD.