[Retracted] Immunomodulation in Human Dendritic Cells Leads to Induction of Interferon-Gamma Production by Leishmania donovani Derived KMP-11 Antigen via Activation of NF-κB in Indian Kala-Azar Patients

Table 1

Cytokine profile of CD4+ T-cell lymphocytes differentiated in response to stimulation with L.donovani specific KMP-11 antigen.

Source of APCs	Cytokines	Frequency of cytokine producing CD4+ T cells obtained after stimulation with different Leishmania antigen
		Ex  vivo	KMP-11
Macrophage
Active VL (𝑛=10)	IFN-𝛾	2.765±0.3928	6.88±1.244^∗∗
	IL-10	4.42±0.5656	27.4±3.512
Healthy control (𝑛=10)	IFN-𝛾	2.85±0.4606	3.08±0.3467
	IL-10	1.89±0.2023	1.73±0.1322
Monocyte-derived dendritic cell
Active VL (𝑛=10)	IFN-𝛾	2.29±0.2415	17.48±2.17^∗∗
	IL-10	19.51±1.608	11.34±0.916
Healthy control (𝑛=10)	IFN-𝛾	2.98±0.5026	3.58±0.432
	IL-10	1.97±0.0928	1.73±0.144

(i) Mean ± standard error.
(ii) These values came from a total lymphocyte gate (R1).
(iii) Frequencies after 5 days of culture with the indicated antigen (KMP: 10 μg/mL) and PHA (10 μg/mL).
(iv) Significantly different from the frequency ex vivo using student’s 𝑡-test with comparison of all pairs and a 𝑃 value of <0.05  ex vivo and KMP-11 antigen (**).