Evaluation of Buspirone on Streptozotocin Induced Type 1 Diabetes and Its Associated Complications

Table 4

Effect of buspirone on hemodynamic and cardiac oxidative stress parameters.

Parameters	CON	COB	DIC	DIB
Blood pressure (mm Hg)	1311±4.07	134±3.58	151±4.83^∗	141±2.36
Heart rate (beats/min)	381±1010	392±8.69	298±12.84^∗	330±9.39
Malondialdehyde (nmoles/mg protein)	0.66±0.04	0.71±0.06	1.67±0.11^∗	1.20±0.09^#
Glutathione (μg/mg protein)	2.17±0.09	1.54±0.05	0.97±0.01^∗	1.47±0.02^#
Superoxide dismutase (U/mg protein)	4.11±0.05	4.03±0.04	2.53±0.01^∗	2.77±0.02^#

∗Significantly different from normal control (𝑃<0.05).
^#Significantly different from diabetic control (𝑃<0.05).
Values are expressed as mean ± SEM of 6 experiments.
CON: normal control, COB: control treated with buspirone, DIC: diabetic control, and DIB: diabetic treated with buspirone.