Evaluating the Effects and Safety of Intravenous Lipid Emulsion on Haloperidol-Induced Neurotoxicity in Rabbit

<table>Evaluation of cataleptic score (malpositioned forelimb on back) changes in haloperidol (HAL) intoxicated rabbits that received various doses of intravenous lipid emulsion (ILE) or normal saline. Starting of HAL or AWD infusion: zero time. Infusion of ILE or normal saline was started at 0.5 hour. <svg height="17.825001" id="M14" style="vertical-align:-3.13504pt" version="1.1" viewbox="0 0 69.150002 17.825001" width="69.150002" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg>, ADW: aseptic distilled water. At the second hour, <svg height="11.175" id="M17" style="vertical-align:-0.0pt" version="1.1" viewbox="0 0 10.9375 11.175" width="10.9375" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg>  value of difference between means of latency time of ILE 12 and ILE 18 with HAL + normal saline &lt;0.05. At the third hour, <svg height="11.175" id="M18" style="vertical-align:-0.0pt" version="1.1" viewbox="0 0 10.9375 11.175" width="10.9375" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> value of difference between means of latency time of ILE 6, ILE 12, and ILE 18 with Hal + normal saline &lt;0.001.</table>

BioMed Research International

fig3

Figure 3

Figure 3: Evaluating the Effects and Safety of Intravenous Lipid Emulsion on Haloperidol-Induced Neurotoxicity in Rabbit 