Perinatal Nitric Oxide Therapy Prevents Adverse Effects of Perinatal Hypoxia on the Adult Pulmonary Circulation

Table 1

Body weight and number of alive pups per litter at 5 days after birth.

5-day-old mice	Control; 𝑛=119	Perinatal hypoxia; 𝑛=46	Perinatal hypoxia + iNO; 𝑛=98
Body weight (g)	2.90 ± 0.03	2.60±0.07^∗	2.72±0.04^∗
Pups per litter	7.0 (4–10)	4.5 (3–7)^∗	6.0 (3–7)^∗

Body weight and number of alive pups per litter were recorded at the end of the perinatal exposure to normoxia (control), hypoxia, or hypoxia and inhaled NO (iNO). Results are expressed as mean ± SEM for body weight and median (range) for the number of pups per litter; 𝑛 corresponds to the number of animals studied in each group. ∗Significant difference compared to controls (𝑃<0.05, using the nonparametric Mann-Whitney test).