Interleukin-13 Receptor Alpha 2-Targeted Glioblastoma Immunotherapy

Table 1

Chimeric antigen receptors against IL13Rα2.

Chimeric antigen receptors	Mutation	Delivery	Clinical trials
IL13 zetakine [22]	Single (E13Y)	Plasmid	Yes [37, 38]
IL13 CAR [23]	Double (E13K and R109K)	Retrovirus	No
HER2.CD28 and IL13Rα2.CD28 biCAR [39]	E13K	Retrovirus	No
Multiple [40]	E13K, E13Y, E13Y.K105R, E13K.K105R	Retrovirus	No