Assessment of Acute Oral and Dermal Toxicity of 2 Ethyl-Carbamates with Activity against Rhipicephalus microplus in Rats

Figure 1

Histopathological findings in rats with oral exposure to carbamate LQM 919. (a) Liver section (20x) of an unexposed rat (control). (b) Liver section (20x) of a rat exposed to 2000 mg/kg of carbamate that shows a degenerated area. (c) Previous image magnification (40x) that shows highly euchromatic nuclei (hen), hepatocytes with two nuclei (dn), and pyknotic nuclei (pn). (d) Kidney section (10x) of an unexposed rat (control). (e) Kidney section (10x) of a rat exposed to 2000 mg/kg of carbamate that shows hyaline degenerated foci (discontinuous circle) in the renal cortex. (f) Previous image magnification (40x) that shows hyaline degeneration and pyknotic nuclei (coagulative necrosis).