Research Article
Assessment of Acute Oral and Dermal Toxicity of 2 Ethyl-Carbamates with Activity against Rhipicephalus microplus in Rats
Table 3
Onset and evolution of clinical manifestations observed in rats orally exposed to carbamates LQM 919 or LQM 996.
| | Treatment | Dose (mg/kg b.wt.) | Number of rats () | Clinical signs | Onset of clinical signs (hours p.t.) | Recovery time (hours p.t.) | Time of death or euthanasia (hours p.t.) |
| | LQM 919 | 300 | 1 | Hypotensive shock | 0.016 | | Death
0.016 | | | | 4 | Mild depression in unprovoked and provoked behavior | 1 | 8 to 24 | | | | 2000 | 1 | Weakness and prostration | 1 | 8 to 24 | | | | | 1 | Weakness, prostration, and hypothermia | 1 | | Death
3 | | | | 3 | | 1 | | Euthanasia
8–22 |
| | LQM 996 | 300 | 5 | Mild depression in unprovoked and provoked behavior | 1 | 8 to 24 | | | | 2000 | 3 | Weakness, prostration, and hypothermia | 1 | | Euthanasia
9 | | | | 2 | | 1 | | Death
5 |
|
|
p.t.: posttreatment.
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