Assessment of Acute Oral and Dermal Toxicity of 2 Ethyl-Carbamates with Activity against Rhipicephalus microplus in Rats

Table 5

Effect of the acute dermal exposure of LQM 919 on selected parameters (mean ± SD) in Wistar rats.

Parameter	Group
	Control (corn oil)	Control (corn oil + DMSO)	500 mg/kg	2000 mg/kg	5000 mg/kg
AST (U/L)	201.5±62.90	218.6±79.04	206.4±34.56	171.6±29.33	171.8±31.37
ALT (U/L)	85.87±9.81	86.47±17.24	56.04±26.57	64.86±14.17	84.36±9.71
LDH (U/L)	732.0±129.5	603.0±172.1	643.2±164.6	611.6±198.0	693.2±108.4
GGT (U/L)	1.01±0.51	1.15±1.62	0.18±0.25	0.47±0.50	1.51±0.83
CHE (U/L)	457.5±161.4	360.9±66.32	450.5±114.3	408.7±108.4	462.0±64.06
Creatinine (mg/dL)	0.51±0.23	0.64±0.21	0.59±0.16	0.55±0.16	0.46±0.09
Total protein (g/dL)	6.59±0.45	6.38±0.26	6.13±0.71	6.69±0.62	6.50±0.49
Albumin (g/dL)	2.53±0.99	2.51±0.82	2.66±0.54	2.72±0.75	2.41±0.69
Globulin (g/dL)	4.06±1.20	3.87±1.03	3.48±0.62	3.97±0.18	4.09±0.92
A/G	0.72±0.41	0.73±0.40	0.79±0.21	0.69±0.21	0.64±0.30

AST: aspartate aminotransferase; ALT: alanine aminotransferase; LDH: lactate dehydrogenase; GGT: gamma-glutamyltransferase; CHE: cholinesterase; A/G: albumin and globulin.