Assessment of Acute Oral and Dermal Toxicity of 2 Ethyl-Carbamates with Activity against Rhipicephalus microplus in Rats

Table 6

Effect of the acute oral exposure of LQM 996 on selected parameters (mean ± SD) in Wistar rats.

Parameter	Group
	Control (corn oil)	Control (corn oil + DMSO)	5 mg/kg	50 mg/kg	300 mg/kg	2000 mg/kg
AST (U/L)	197.6±72.89	162.3±46.69	164.1±30.03	175.3±98.03	158.2±41.58	162.5±9.78
ALT (U/L)	66.92±14.34	68.64±23.14	72.00±13.68	79.42±37.81	67.70±10.77	48.80±9.67
LDH (U/L)	683.8±164.1	493.4±114.2	644.2±220.0	472.6±174.1	390.2±90.32	489.6±179.1
GGT (U/L)	1.27±0.47	1.06±0.68	1.09±0.46	1.86±0.50	0.87±0.15	0.36±0.50
CHE (U/L)	315.4±56.9	324.3±82.1	453.1±125.2	417.5±98.58	492.5±79.73	382.0±85.15
Creatinine (mg/dL)	0.44±0.03	0.49±0.12	0.50±0.07	0.50±0.04	1.13±0.64^∗	0.50±0.03
Total protein (g/dL)	6.30±0.99	5.87±0.86	6.12±0.38	5.45±0.22	5.62±0.78	5.18±0.32
Albumin (g/dL)	2.04±0.78	2.57±0.73	2.06±0.95	2.27±0.53	2.45±0.14	2.35±0.66
Globulin (g/dL)	4.26±0.92	3.31±0.75	4.05±0.85	3.19±0.50	3.17±0.69	2.83±0.74
A/G	0.52±0.29	0.81±0.30	0.57±0.37	0.77±0.27	0.79±0.14	0.90±0.35

AST: aspartate aminotransferase; ALT: alanine aminotransferase; LDH: lactate dehydrogenase; GGT: gamma-glutamyltransferase; CHE: cholinesterase; A/G: albumin and globulin. *Significant difference with the control group (𝑃<0.05).