The Laboratory of Genetics and Physiology 2: Emerging Insights into the Controversial Functions of This RIG-I-Like Receptor

Figure 2

RLRs signaling pathway and the possible regulatory manners of LGP2. Viral dsRNA was recognized by RIG-I or MDA5, triggering signal transduction to nucleus and inducing the production of type I IFN and proinflammatory cytokines. The cooperative or competitive roles of LGP2 in RLR pathway activation are controversial. Whether the interaction between viral protein and LGP2 shows any antiviral response remains unclear, and the affection of LGP2 on IRF3 activation still needs more exploration.