Female Aging Alters Expression of Human Cumulus Cells Genes that Are Essential for Oocyte Quality
Figure 4
(a) Venn diagram representing the number of miRNAs retrieved from the GenGo analysis. The genes overexpressed in each age category were submitted to GenGo to identify their potential miRNA regulators. 249 miRNAs were retrieved for the group, 251 for the , and 211 for the CColder. The Venn diagram drawn after these lists shows that the majority is common to the three age categories. The miRNAs that are detected in the cumulus cells by using deep-sequencing approach [21] are shown in pink. (b) Schematic representation of some of the validated genes of the three pathways and processes discussed in this work and their miRNA regulators. Only the miRNAs that were found in the CCs small RNA sequencing and reported in the literature to be experimentally validated were represented. indicates the validated genes with no miRNA regulator that meets these criteria.
