Research Article

Modulation of Wolframin Expression in Human Placenta during Pregnancy: Comparison among Physiological and Pathological States

Figure 2

(a) Low wolframin expression in the endothelial cells inside placental villi from the third trimester vaginal delivery (VD), 300x; (b) higher magnification showing wolframin immunopositivity localized in the cytotrophoblast cells (arrow) from the VD, 640x; (c) moderate wolframin immunopositivity in the endothelial cells lining blood vessels of placental villi from caesarean section (CS), 300x; (d) higher magnification showing moderate wolframin expression in endothelial cells and in cytotrophoblast cells (arrow) of placental villi from CS, 640x; (e) low expression level of wolframin in the stroma and endothelial cells of the third trimester placental villi from diabetic women, 300x; (f) higher magnification showing low wolframin expression localized almost exclusively in the stroma and endothelial cells of placenta from diabetic women; no immunopositivity was shown in both cytotrophoblast and syncytiotrophoblast.
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