BioMed Research International / 2014 / Article / Tab 1 / Review Article
The Endothelium, A Protagonist in the Pathophysiology of Critical Illness: Focus on Cellular Markers Table 1 Overview endothelial progenitor cells in sepsis.
Study group Study type Phenotype EPC Main findings Becchi et al. [15 ] Case-control sepsis (
) CD34+ KDR+ in isolated PBMC CD34+ KDR+ CD133+ in isolated CD34+ cells (i) Increased % EPC the first 72 h after sepsis (ii) EPC severe sepsis ≫ sepsis Cribbs et al. [16 ] Case-control sepsis (
) CFU-EPC (i) Decreased CFU-EPC in sepsis (ii) Inversely associated with SOFA Luo et al. [17 ] MODS model in pigs (
) CD133+ CD34+ in WB CFU-EPC Migration to VEGF Decreased EPC, CFU-EPC and migratory function in MODS Mayr et al. [18 ] LPS in healthy volunteers (
) CD34+ KDR+ CD133+ EPC in WB CFU-EPC (i) Decrease in EPC number with nadir at 6 h post LPS (ii) Decreased CFU-EPC nadir 4 h after LPS Patschan et al. [19 ] Case-control sepsis (
) KDR+ CD133+ in isolated PBMC CFU-EPC (i) Increased % EPC in sepsis (ii) Decreased CFU-EPC in sepsis Rafat et al. [20 ] Case-control sepsis (
) CD34+ KDR+ CD133+ in isolated PBMC (i) Increased % EPC in sepsis (ii) Lower % EPC in nonsurvivors Schlichting et al. [21 ] Case-control severe sepsis (
) CFU-EPC No difference van Ierssel et al. [22 ] Case-control severe sepsis (
) CD34+ KDR+ in WB Migration to SDF-1
and VEGF (i) Decreased absolute number (ii) Decreased migratory capacity (iii) Impending organ dysfunction the first week was associated with lower EPC and a trend to impaired migration
CFU-EPC: EPC colony forming units; EPC: endothelial progenitor cells, LPS: lipopolysaccharides; MODS: multiorgan dysfunction syndrome; PBMC: peripheral blood mononuclear cells; SDF-1
: stromal derived factor 1
; SOFA: sequential organ failure assessment; VEGF: vascular endothelial growth factor; WB: whole blood.