Review Article
The Endothelium, A Protagonist in the Pathophysiology of Critical Illness: Focus on Cellular Markers
Table 2
Overview endothelial microparticles in sepsis.
| Study group | Study design | Detection method | Phenotype EMP | Main findings |
| Joop et al. [23] | Case-control MODS and sepsis () | Flow cytometry isolated MP frozen samples | CD62E+/ Annexin V+ CD144+/ Annexin V+ | (i) Lower number CD62E+ EMP (ii) Unchanged number CD144+ EMP |
| Mortaza et al. [24] | Rat cecal ligation and puncture model | Flow cytometry PFP | CD54+/ Annexin V+ | (i) Unchanged EMP in sepsis (ii) Septic MP caused vasoplegic shock in healthy rats |
| Mostefai et al. [25] | Case-control sepsis () mouse model: injection of septic MP | Flow cytometry PFP frozen samples | CD146+ | (i) Increased EMP in sepsis (ii) Septic MP induced increased responsiveness to vasoconstrictors in aortic rings |
| Nieuwland et al. [26] | Case-control meningococcal sepsis () | Flow cytometry isolated MP | CD62E+/ Annexin V+ | Nonsignificant increase in sepsis |
| Ogura et al. [27] | Case-control severe SIRS (, sepsis = 12) | Flow cytometry PRP | CD54+ CD31+ | EMP increased in sepsis |
| Pérez-Casal et al. [28] | Case control study of APC treated sepsis patients | Flow cytometry isolated MP | CD13+ EPCR+ | Increased CD13+ EPCR+ MP |
| Soriano et al. [29] | Case control severe sepsis () | Flow cytometry PPP | CD31+ CD42b− | (i) EMP higher in severe sepsis (ii) EMP higher in survivors (iii) Negative correlation with SOFA on D2 and D3 |
| van Ierssel et al. [22] | Case-control severe sepsis () | Flow cytometry PPP | CD31+ CD42b− | Unchanged number of EMP versus healthy controls |
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EMP: endothelial microparticles; MODS: multiorgan dysfunction syndrome; MP: microparticle; PFP: platelet free plasma; PPP: platelet poor plasma; PRP: platelet rich plasma; SOFA: sequential organ dysfunction assessment.
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