Protecting Intestinal Epithelial Cell Number 6 against Fission Neutron Irradiation through NF-κB Signaling Pathway

Figure 1

The changes of IEC-6 appearance (IPCM, magnification of 200x). (a) Control, the IEC-6 cells looked like applanatus polygon or fusiform shape and aggregated together shape of chrysanthemum thyse appearance. (b) Six h after neutron radiation of 4Gy, the IEC-6 cells swelled and became approximately round shaped and lots of dead cells floated on the culture solution. (c) Twenty-four h after neutron radiation of 4Gy, the cells were injured more seriously than those of 6 h after neutron irradiation. ((d), (e)) Neutron irradiation of 4Gy with LY294002 treatment group cells, the cells were injured more seriously than those of the neutron irradiation group.

(a) Control

(b) Six h after neutron radiation of 4Gy

(c) Twenty-four h after neutron radiation of 4Gy

(d) Six h after neutron radiation of 4Gy with LY294002 treatment

(e) Twenty-four h after neutron radiation of 4Gy with LY294002 treatment