Study Country Parkinsonism type Prevalence, % Number of study population Number of affected patients Onset age, y Expansion number of patients Levodopa response Cerebellar signs Noticeable clinical features Long term follow-up complications SCA2 Shan et al. (2001) [4 ] Taiwan Familial 8.69 23 patients in 19 families 2 50/50 36/37 + − Both tremor dominant with slow saccade and CIT-PET (+), nystagmus (+) in 1 patient Kock et al. (2002) [85 ] Mixed Familial DRP 0 64 young onsets, 32 late onsets (age of onset >50) 0 Payami et al. (2003) [6 ] USA Familial DRP 1.5 136 2 36 (Caucasian)/60 (Hispanic) 33/35 + − Evidences of peripheral neuropathy (+) in 1 patient ( ) D+, MF+ Svetel et al. (2003) [86 ] Serbia Familial YO-DRP 0 40 0 Lu et al. (2004) [10 ] Taiwan Familial 5.38 130 patients in 41 families 7 45.8 ± 13.9 35–38 + +a 1 patient with mild slow saccades and 1 patient with combined mild dystonia D+c Simon-Sanchez et al. (2005) [13 ] USA Familial 0.88 114 1 55 (Caucasian) 37 + Lim et al. (2006) [26 ] Singapore Familial IPD 0 46 0 Charles et al. (2007) [23 ] France Familial ADP 2 178 patients in 164 families 3 29–64 (50.1 ± 13.2)d 37–39d + − D 22%, MF 14%d Lin et al. (2007) [60 ] Taiwan Familial 0 13 0 Modoni et al. (2007) [24 ] Italy Familial 2.5 79 1 48 38 + − Tremor dominant and CIT-PET (+) D−, MF− Wang et al. (2009) [27 ] China Familial PD 1.5 66 2 42/35 36/36 + − CIT-PET (+) Kock et al. (2002) [85 ] Mixed Sporadic DRP 0 174 0 Svetel et al. (2003) [86 ] Serbia Sporadic YO-DRP 0 45 0 Shan et al. (2004) [11 ] Taiwan Sporadic PD and atypical parkinsonism 0.4 242 1 in PD group and 0 in atypical group 56 37 + − CIT-PET (+) D+, MF+ Lim et al. (2006) [26 ] Singapore Sporadic YO-IPD 2.2 45 1 50 36 + − Postural instability Tan et al. (2007) [61 ] Singapore Sporadic atypical parkinsonism patients with poor levodopa response 0 100 0 Lin et al. (2007) [60 ] Taiwan Sporadic 0 60 0 Modoni et al. (2007) [24 ] Italy Sporadic 0 145 0 Kim et al. (2007) [28 ] Korea Sporadic PD 0.43 468 2 70/55 35/34 + − Saccadic movement dysfunction, hyporeflexia in 1 patient Kim et al. (2007) [28 ] Korea Sporadic MSA-P 0.74 135 1 59 32 Minimal + MSA-P type MRI: cerebellar atrophy Wang et al. (2009) [27 ] China Sporadic 0.5 386 2 29/37 37/36 + − Yun et al. (2011) [29 ] Korea Sporadic PD 0 386 0 Yun et al. (2011) [29 ] Korea Sporadic MSA 0.72 138 1 55 32 − + MSA-P type CIT-PET (+) MRI: cerebellar atrophy SCA3 Svetel et al. (2003) [86 ] Serbia Familial YO-DRP 0 40 0 Simon-Sanchez et al. (2005) [13 ] USA Familial 0 114 0 Lim et al. (2006) [26 ] Singapore Familial PD 0 46 0 Lin et al. (2007) [60 ] Taiwan Familial 0 13 0 Charles et al. (2007) [23 ] France Familial ADP 0 178 patients in 164 families 0 Wang et al. (2009) [27 ] China Familial 3 66 4 46/25/40/39 65/69/73/67 + +b CIT-PET (+) Svetel et al. (2003) [86 ] Serbia Sporadic YO-DRP 0 45 0 Lim et al. (2006) [26 ] Singapore Sporadic YO-IPD 0 45 0 Lin et al. (2007) [60 ] Taiwan Sporadic 0 60 0 Tan et al. (2007) [61 ] Singapore Sporadic atypical parkinsonism patients with poor levodopa response 0 100 0 Wang et al. (2009) [27 ] China Sporadic 0.8 386 3 67/36/38 58/64/67 + − Yun et al. (2011) [29 ] Korea Sporadic PD 0 386 0 Yun et al. (2011) [29 ] Korea Sporadic MSA 0 138 0 SCA17 Hernandez et al. (2003) [43 ] USA Familial 0 51 0 Lim et al. (2006) [26 ] Singapore Familial PD 0 46 0 Charles et al. (2007) [23 ] France Familial ADP 0 178 patients in 164 families 0 Kim et al. (2009) [21 ] Korea Familial PD 7.41 27 2 44/50 43/45 + − D+, MF+ Hernandez et al. (2003) [43 ] USA Familial 0 59 0 Wu et al. (2004) [19 ] Taiwan Sporadic PD 0.38 264 1 75 46 + − Lim et al. (2006) [26 ] Singapore Sporadic YO-IPD 0 45 0 Kim et al. (2009) [21 ] Korea Sporadic PD 0.66 904 6 Mean 53.75 (44–61) 43/44 + − Kim et al. (2009) [21 ] Korea Sporadic MSA 0.89 223 2 61/54 29–46 − + Yun et al. (2011) [29 ] Korea Sporadic PD 0.78 386 3 47/66/62 45/44/43 + Yun et al. (2011) [29 ] Korea Sporadic MSA 2.89 138 4 54/59/74/62 46/44/43/43 Partial + MSA-P type