Morphine Reduces Myocardial Infarct Size via Heat Shock Protein 90 in Rodents

Figure 3

Structure of HSP90α and HSP90β. (a) General schematic of HSP90α and HSP90β, each having an N-terminus ATP site, substrate site, and C-terminus TPR motif. (b) Presence of C-terminus EEVD motif for both HSP90 and HSP70 in humans (underlined). Other human HSP family sequences lacked the C-terminus motif. Sequences obtained from the Swiss-Prot database: P07900 HS90_HUMAN, P08238 HS90B_HUMAN, P08107 HSP71_HUMAN, P61604 CH10_HUMAN, Q9UJY1 HSPB8_HUMAN, P04792 HSPB1_HUMAN, P09601 HMOX1_HUMAN, P25685 DNJB1_HUMAN, Q0VDF9 HSP7E_HUMAN, P11021 GRP78_HUMAN, P14625 ENPL_HUMAN, and Q92598 HS105_HUMAN.

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