Morphine Reduces Myocardial Infarct Size via Heat Shock Protein 90 in Rodents

<div>Computational analysis of HSP90<i>α</i> and HSP90<i>β</i> C-terminus. (a) HSP90<i>α</i> and (b) HSP90<i>β</i> prediction of Ser or Thr phosphorylation probability, using NetPhos 2.0. (c) Conservation of HSP90<i>β</i> EEVD sequence motif at C-terminus, including a serine, 7 amino acids from the C-terminus. In particular, this EEVD sequence is strongly conserved throughout evolution, in addition to the phosphorylation site near the C-terminus (orange box). Sequences obtained from the Swiss-Prot database: P08238 HS90B_HUMAN, Q76LV1 HS90B_BOVIN, P34058 HSPB_RAT, Q04619 HS90B_CHICK, O57521 HS90B_DANRE, O02192 HSP83_DROAV, Q18688 HSP90_CAEEL, and P02829 HSP82_YEAST.</div>

BioMed Research International

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Figure 6

Figure 6: Morphine Reduces Myocardial Infarct Size via Heat Shock Protein 90 in Rodents 