Prevalence of Human Papillomavirus Variants and Genetic Diversity in the L1 Gene and Long Control Region of HPV16, HPV31, and HPV58 Found in North-East Brazil

Table 3

HPV16 L1 sequence variations at the genome and protein level and the putative biological function affected.

Genome position	Variation	AA changed	Protein position	Number of isolates	Biological function
5862	C/T	H102Y	-C	5/14	MHC Class-I/MHC Class-II
5909	T/C	—		5/14
5981	G/A	—		1/14
6023	A/T	—		1/14
6163	C/A	T202N	EF-loop	5/14	B-cell/MHC Class-I
6176	A/C	N207T	EF-loop	2/14	B-cell/MHC Class-I/MHC Class-II
6240	C/G	H228D	EF-loop	14/14	B-cell/MHC Class-I
6245	T/C	—		5/14
6300	A/C	—		1/14
6315	A/G	—		4/14
6436	A/G	T292A	FG-loop	5/14	MHC Class-I/MHC Class-II
6484	T/C	—		1/14
6561	C/T	S308P		5/14
6570	T/G	—		1/14
6697	A/C	T379P	HI-loop	5/14	B-cell/MHC Class-I
6723	G/A	—		5/14
6805	A/T	T415S	h2	1/14	MHC Class-I/MHC Class-II/VLP formation
6856	C/T	—		5/14
6867	C/T	—		5/14
6903	Ins ATC	Ins T and S 448	h4	14/14	MHC Class-I/
6955	Del GAT	Del D 465	h4--J		MHC Class-II/VLP formation
6972	C/T	—		5/14
6996	G/A	—		5/14

(—) Synonymous variations with regard to the prototype reference K02718.1. Del: deletion,  Ins: insertion,  H: histidine,  Y: tyrosine,  T: threonine,  N: asparagine,  D: aspartic acid,  A: alanine,  S: serine,  P: proline,  and Q: glutamine.