Prevalence of Human Papillomavirus Variants and Genetic Diversity in the L1 Gene and Long Control Region of HPV16, HPV31, and HPV58 Found in North-East Brazil
Table 3
HPV16 L1 sequence variations at the genome and protein level and the putative biological function affected.
Genome position
Variation
AA changed
Protein position
Number of isolates
Biological function
5862
C/T
H102Y
-C
5/14
MHC Class-I/MHC Class-II
5909
T/C
—
5/14
5981
G/A
—
1/14
6023
A/T
—
1/14
6163
C/A
T202N
EF-loop
5/14
B-cell/MHC Class-I
6176
A/C
N207T
EF-loop
2/14
B-cell/MHC Class-I/MHC Class-II
6240
C/G
H228D
EF-loop
14/14
B-cell/MHC Class-I
6245
T/C
—
5/14
6300
A/C
—
1/14
6315
A/G
—
4/14
6436
A/G
T292A
FG-loop
5/14
MHC Class-I/MHC Class-II
6484
T/C
—
1/14
6561
C/T
S308P
5/14
6570
T/G
—
1/14
6697
A/C
T379P
HI-loop
5/14
B-cell/MHC Class-I
6723
G/A
—
5/14
6805
A/T
T415S
h2
1/14
MHC Class-I/MHC Class-II/VLP formation
6856
C/T
—
5/14
6867
C/T
—
5/14
6903
Ins ATC
Ins T and S 448
h4
14/14
MHC Class-I/
6955
Del GAT
Del D 465
h4--J
MHC Class-II/VLP formation
6972
C/T
—
5/14
6996
G/A
—
5/14
(—) Synonymous variations with regard to the prototype reference K02718.1. Del: deletion, Ins: insertion, H: histidine, Y: tyrosine, T: threonine, N: asparagine, D: aspartic acid, A: alanine, S: serine, P: proline, and Q: glutamine.